Cardiomyocyte electrical-mechanical synchronized model for high-content, dose-quantitative and time-dependent drug assessment
نویسندگان
چکیده
منابع مشابه
Independent assessment of source transit time for the BEBIG SagiNova® high dose rate brachytherapy afterloader
Introduction: The dwell time and transit time components contribute to the overall delivered dose to patients in high dose rate (HDR) brachytherapy treatments. The transit time results from source entry and exit as well as source movements between dwell positions. It depends on various parameters such as the source speed profile, source indexer distance to dwell position, and ...
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Myocardial infarction is often associated with abnormalities in electrical function due to a massive loss of functioning cardiomyocytes. This work develops a mesh, consisting of aligned composite nanofibers of polyaniline (PANI) and poly(lactic-co-glycolic acid) (PLGA), as an electrically active scaffold for coordinating the beatings of the cultured cardiomyocytes synchronously. Following dopin...
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This paper deals with a two-warehouse inventory model for deteriorating items with time dependent demand and partial backlogging under inflation. It is assumed that deterioration of items follows two-parameter Weibull distribution and demand rate varies exponentially with time. Shortages are allowed and partial backlogging depends on waiting time of next replenishment. A numerical example is pr...
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BACKGROUND Mechanical assist device therapy has emerged recently as an important and rapidly expanding therapy in advanced heart failure, triggering in some patients a beneficial reverse remodeling response. However, mechanisms underlying this benefit are unclear. METHODS AND RESULTS In a model of mechanical unloading of the left ventricle, we observed progressive myocyte atrophy, autophagy, ...
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ژورنال
عنوان ژورنال: Microsystems & Nanoengineering
سال: 2021
ISSN: 2055-7434
DOI: 10.1038/s41378-021-00247-0